Nice job, had me fooled. Regarding your question, there is a June 2007 review article in Nature Reviews- Genetics, volume 8, titled Genome-wide transcription and the implications for genomic organization, with authors Philipp Kapranov, Aaron T. Gillingham, and Thomas R. Gingeras. It is a scientific establishment paper, but it does acknow…
Nice job, had me fooled. Regarding your question, there is a June 2007 review article in Nature Reviews- Genetics, volume 8, titled Genome-wide transcription and the implications for genomic organization, with authors Philipp Kapranov, Aaron T. Gillingham, and Thomas R. Gingeras. It is a scientific establishment paper, but it does acknowledge the lack of understanding of genetics, though you must read it through a scientist's understanding of language, and realize all conditional words or phrases (might, could, suggest, unclear, some evidence, estimates vary, not fully understood, etc.) should be interpreted as "we have no clue." Anything known will be stated bluntly by the author, as the typical paper contains few knowns. My takeaway from this review was that interactions between DNA molecules is so complex that it is impossible to know what effect any given mutation would have on an organism. And, that the role of RNA, about which little is known, plays a far greater than thought leading to even less understanding of genetics overall. The review paper costs money though I have a digital copy I could share with you. I have a yahoo address at my name.
Nice job, had me fooled. Regarding your question, there is a June 2007 review article in Nature Reviews- Genetics, volume 8, titled Genome-wide transcription and the implications for genomic organization, with authors Philipp Kapranov, Aaron T. Gillingham, and Thomas R. Gingeras. It is a scientific establishment paper, but it does acknowledge the lack of understanding of genetics, though you must read it through a scientist's understanding of language, and realize all conditional words or phrases (might, could, suggest, unclear, some evidence, estimates vary, not fully understood, etc.) should be interpreted as "we have no clue." Anything known will be stated bluntly by the author, as the typical paper contains few knowns. My takeaway from this review was that interactions between DNA molecules is so complex that it is impossible to know what effect any given mutation would have on an organism. And, that the role of RNA, about which little is known, plays a far greater than thought leading to even less understanding of genetics overall. The review paper costs money though I have a digital copy I could share with you. I have a yahoo address at my name.
Thank you, I found it:
https://www.nature.com/articles/nrg2083
My "unpaywall" browser plug-in confirms it's not publicly available. I'll gladly accept your digital copy offer. Will send email now.